Non sedating antihistamines definition azdg dating powered by azdg

According to the International Guidelines for the management of urticaria and angioedema non-sedating, second generation antihistamines (NSAHs) are recommended for the treatment of CU [].

The best responses were obtained with fexofenadine, rupatadine, and bilastine.The statistical comparison of the data is shown in Figure .According to Humphreys and Hunter up to 40% of patients with CU may not achieve good control with antihistaminic therapy [].They reported that out of 390 CU patients who were treated with antihistamines 44% responded well, 29% became asymptomatic, and 15% showed partial improvement.When available, efficacy data were pooled from different studies that utilized the same drug dose.

The proportions of patients responding to the therapy were compared using the Fisher’s exact test with a significance level of p Twelve studies that investigated the effects of higher doses of NSAHs were identified in this search.Six articles included patients with CSU/CIU and other 2 studied patients with acquired cold urticaria.Four investigations chose mean pruritus scores as the main outcome, and the other 4 utilized the percentage of symptom-free patients as the main parameter of efficacy.Among those, 3 papers dealing with the treatment of patients with CSU were excluded from analysis because of their open design, 2 employing cetirizine and one that utilized ebastine [].Another study by Metz et alwas also excluded because it assessed exclusively the effects of a 20 mg dose of rupatadine in patients with acquired cold urticaria whereas no comparisons with other doses of the drug were done [ summarizes the details from 8 double-blind, placebo-controlled studies included in this report.For analysis of the efficacy, only double-blind, placebo-controlled studies were selected, whereas uncontrolled studies were excluded.